Unintentional or unexplained weight loss — especially when it occurs rapidly or without changes to diet or physical activity — is often a sign that something deeper may be affecting your health. While some causes may be relatively harmless, others could be indicative of underlying medical conditions such as digestive disorders, cancer, infections, or endocrine problems.

In Buffalo and Western New York, patients experiencing sudden or persistent weight loss turn to Great Lakes Medical Imaging (GLMI) for answers. We work closely with referring physicians to provide advanced, non-invasive imaging studies that help identify what’s going on inside the body. With tools like CT scans, MRI, and ultrasound, we’re able to visualize internal organs, tissues, and systems to assist in pinpointing the cause of unexplained weight loss.

When Should You Be Concerned About Weight Loss?

It’s normal for body weight to fluctuate slightly over time. However, **losing more than 5% of your body weight over 6–12 months without trying** is typically considered a red flag. For example, a 160-pound person losing 8 pounds unintentionally should consider medical evaluation.

Symptoms that may accompany concerning weight loss include:

• Loss of appetite
• Chronic fatigue or weakness
• Night sweats or fever
• Abdominal pain or bloating
• Changes in bowel habits
• Persistent cough or shortness of breath

If you are experiencing any of these symptoms along with weight loss, your physician may recommend imaging studies as part of a broader diagnostic plan.

Imaging Modalities Used to Investigate Unexplained Weight Loss

CT Scan (Computed Tomography)

CT scans are often the first imaging test ordered when evaluating unexplained weight loss. CT provides cross-sectional images of the chest, abdomen, and pelvis, allowing radiologists to assess the organs for signs of cancer, infection, inflammation, or other abnormalities. It is especially helpful in identifying tumors, gastrointestinal disorders, or lymph node enlargement that might not be evident through physical exam alone.

MRI (Magnetic Resonance Imaging)

MRIs offer detailed views of soft tissues and are useful when CT doesn’t provide a complete picture or when radiation exposure needs to be avoided. MRI is particularly helpful for evaluating the brain, spine, liver, pancreas, or endocrine system — all of which can play a role in unexplained weight loss when affected by disease.

Ultrasound

Ultrasound is a non-invasive, radiation-free imaging option that is often used to assess the thyroid, liver, gallbladder, kidneys, or reproductive organs. It can help detect inflammation, cysts, or organ enlargement that may be contributing to weight loss, and is often part of the initial work-up for gastrointestinal or hormonal conditions.

PET/CT Scan

When cancer is suspected as a possible cause of unexplained weight loss, a PET/CT scan may be ordered. This advanced technology highlights metabolic activity throughout the body, allowing physicians to detect tumors or abnormal cell growth not always visible on standard imaging tests.

Possible Conditions Imaging Can Help Diagnose

Imaging plays a key role in diagnosing or ruling out several potential causes of unintentional weight loss:

• Cancer – Imaging may detect tumors or metastasis in organs such as the lungs, liver, pancreas, or colon.
• Gastrointestinal disorders – Conditions like Crohn’s disease, ulcerative colitis, or chronic infections can be visualized through abdominal CT or MRI.
• Hyperthyroidism – Thyroid ultrasound can help detect nodules or thyroid inflammation causing accelerated metabolism.
• Chronic infections – Imaging may reveal hidden infections in the lungs or abdomen that are driving systemic symptoms.
• Neurological disorders – MRI of the brain may help evaluate for neurodegenerative conditions affecting appetite or metabolism.

What to Expect During Imaging at GLMI

When you visit any of our convenient Western New York locations, you can expect prompt, professional care from experienced radiologists and technologists. Your imaging exam will be tailored to your specific symptoms and medical history. Most exams are completed within 30–60 minutes, and our team ensures a comfortable, supportive environment throughout your visit.

Once your scan is complete, your images will be interpreted by one of our board-certified radiologists. Results are sent promptly to your referring provider to aid in diagnosis and guide next steps in your care plan.

Why Buffalo Residents Choose GLMI for Diagnostic Imaging

At GLMI, we take pride in being one of Western New York’s most trusted imaging providers. Our facilities are equipped with the latest technology to ensure accuracy, and our experienced staff delivers personalized care with every scan.

We offer:

• Low-dose CT for reduced radiation exposure
• High-field MRI for detailed soft tissue analysis
• Non-invasive ultrasound evaluations
• Fast scheduling and short wait times

Concerned About Unexplained Weight Loss? We Can Help.

If you or a loved one are experiencing sudden, unexplained weight loss, don’t wait to take action. Contact Great Lakes Medical Imaging today to schedule the appropriate imaging study and take the next step toward answers and peace of mind.

Medical Disclaimer

This article is for general informational purposes only and is not a substitute for professional medical advice. Always consult with a qualified healthcare provider regarding any medical conditions or concerns you may have.